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Higher serum phenylalanine concentration is associated with more rapid telomere shortening in men
aging amino acids telomeres phenylalanine telomere shortening longitudinal study
2018/11/12
Background: Telomere length and telomere shortening are associated with age-related health outcomes. Only a few studies have been able to longitudinally report on factors that are associated with chan...
Leukocyte telomere length pattern in a Chuvash population that experienced mass famine in 1922–1923: a retrospective cohort study
cohort study famine heritability starvation telomeres
2018/12/18
Background: To our knowledge, there are no experimental studies that have addressed the effects of starvation on the maintenance of telomere length. Two epidemiologic studies that have addressed this ...
Leukocyte telomere length is related to appendicular lean mass: cross-sectional data from the Berlin Aging Study II (BASE-II)
appendicular lean mass BASE-II leukocytes muscle mass sarcopenia telomere length
2018/11/23
Background: Age-related progressive loss of muscle mass is an increasing problem in our aging society, affecting physical ability, risk of falls, and need for health care. Telomere length has been rec...
Effect of Intensive Exercise in Early Adult Life on Telomere Length in Later Life in Men
Aging athlete DNA repeats physical activity
2015/8/28
A career as an elite-class male athlete seems to improve metabolic heath in later life and is also associated with longer life
expectancy. Telomere length is a biomarker of biological cellular agein...
Movement-Based Behaviors and Leukocyte Telomere Length among US Adults
AGING EPIDEMIOLOGY PHYSICAL ACTIVITY NHANES
2017/4/20
Introduction: Short leukocyte telomere length (LTL) has become a hallmark characteristic of aging. Some, but not all, evidence suggests that physical activity (PA) may play an important role in attenu...
Consequences of telomerase inhibition and telomere dysfunction in BRCA1 mutant cancer cells
telomerase BRCA breast cancer telomeres
2015/5/21
Telomere maintenance is a critical component of genomic stability. An increasing body of evidence suggests BRCA1, a tumor suppressor gene with a variety of functions including DNA repair and cell cycl...
Telomere Maintenance Mechanisms: Prognostic and Therapeutic Implications for the Pathologist and Oncologist
Telomere Maintenance Mechanism Neoplasia Sarcoma Glioblastoma Review
2013/1/31
In neoplasia, telomere maintenance mechanisms (TMMs) can be prognostic and may direct therapy in the future. Two types of TMM, telomerase and recombination-based alternative lengthening of telomeres (...
Age Prediction in the Chickens Using Telomere Quantity by Quantitative Fluorescence In situ Hybridization Technique
Chickens Telomere Aging Age Prediction Fluorescence In situ Hybridization
2016/5/6
Telomeres are special structures at the ends of eukaryotic chromosomes. Vertebrate telomeres consist of tandem repeats of conserved TTAGGG sequence and associated proteins. Birds are interesting model...